Structural characterization and bioactivities of hybrid carrageenan-like sulfated galactan from red alga Furcellaria lumbricalis

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DOIResolve DOI: http://doi.org/10.1016/j.foodchem.2010.05.102
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TypeArticle
Journal titleFood Chemistry
Volume124
Issue1
Pages5057; # of pages: 8
SubjectFurcellaria lumbricalis; Purification; Sulphated galactan; Depolymerisation; Bioactivities
AbstractThe red alga, Furcellaria lumbricalis from the coast of the Prince Edward Island (PEI) in Atlantic Canada was extracted with hot water and fractionated with 0.125 M KCl to obtain a carrageenan-like polysaccharide. The polysaccharide was further purified on ion-exchange and gel-permeation chromatography to yield a fraction (FB1) of uniform size and charge, with an average molecular weight of 428 kD. Oligosaccharides generated with acid hydrolysis of FB1 were sequenced using the electrospray ionisation collision induced dissociation tandem mass spectrometry (ES-CID-MS/MS) technique. On the basis of chemical and spectroscopic analysis, FB1 was characterised to be composed of 1,4-linked 3,6-anhydro-galactose (40%),1,3-linked 4-sulphated-galactose (30%), 1,3-linked galactose (20%), 1,4-linked galactose (8%) and 1,4 linked 3-O-methyl-galactose (2%), which makes it be a novel sulphated galactan hybrid. The b-secretase (BACE) inhibition and immunomodulation activities of FB1-derived oligosaccharides were evaluated in vitro.
Publication date
LanguageEnglish
AffiliationNRC Institute for Nutrisciences and Health; NRC Institute for Marine Biosciences; National Research Council Canada
Peer reviewedYes
NPARC number17364208
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Record identifier790d5728-d628-4df8-9803-006f3238c0e9
Record created2011-03-22
Record modified2016-05-09
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