Method for imaging quantum dots during exposure to gamma radiation

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Proceedings titleProceedings of SPIE - The International Society for Optical Engineering
ConferenceFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XI, 23 January 2011 through 26 January 2011, San Francisco, CA
Article number792504
SubjectAmbient lighting; Biomedical applications; CdSe/ZnS quantum dots; Continuous exposure; Emission wavelength; End points; Equivalent concentrations; Gamma radiation; Gamma radiation sources; Gate widths; Green laser; Image samples; Light collection; Nd: YAG; Optical components; Pulse durations; Quantum Dot; Quantum Dots; Real-time dosimetry; Time-Gated Imaging; Time-periods; Dosimetry; Gamma rays; Imaging techniques; Industrial applications; Lighting; Neodymium lasers; Optical properties; Optical systems; Photoluminescence; Portals; Pulsed lasers; Quantum optics; Radiation; Semiconductor quantum dots; Quantum dot lasers
AbstractQuantum dots have been used in a wide variety of biomedical applications. A key advantage of these particles is that their optical properties depend predictably on size, which enables tuning of the emission wavelength. Recently, it was found that CdSe/ZnS quantum dots lose their ability to photoluminescence after exposure to gamma radiation (J. Phys. Chem. C., 113: 2580-2585 (2009). A method for readout of the loss of quantum dot photoluminescence during exposure to radiation could enable a multitude of real-time dosimetry applications. Here, we report on a method to image photoluminescence from quantum dots from a distance and under ambient lighting conditions. The approach was to construct and test a time-gated imaging system that incorporated pulsed illumination. The system was constructed from a pulsed green laser (Nd:YAG, 20 pulses/s, 5 ns pulse duration, ∼5 mJ/pulse), a time-gated camera (LaVision Picostar, 2 ns gate width), and optical components to enable coaxial illumination and imaging. Using the system to image samples of equivalent concentration to the previous end-point work, quantum dot photoluminescence was measureable under ambient room lighting at a distance of 25 cm from the sample with a signal to background of 7.5:1. Continuous exposure of samples to pulsed laser produced no measureable loss of photoluminescence over a time period of one hour. With improvements to the light collection optics the range of the system is expected to increase to several metres, which will enable imaging of samples during exposure to a gamma radiation source. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).
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AffiliationNational Research Council Canada (NRC-CNRC); NRC Steacie Institute for Molecular Sciences (SIMS-ISSM)
Peer reviewedYes
NPARC number21271242
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Record identifier79643c6d-82ca-46bf-bd92-44cc86665be1
Record created2014-03-24
Record modified2016-05-09
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