Antiproliferative quillaic acid and gypsogenin saponins from Saponaria officinalis L. roots

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DOIResolve DOI: http://doi.org/10.1016/j.phytochem.2014.11.021
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TypeArticle
Journal titlePhytochemistry
ISSN0031-9422
Volume113
IssueMay 2015
Pages108120
SubjectSaponins; Saponaria officinalis L.; Caryophyllaceae; Quillaic acid; Gypsogenin; 2D NMR spectroscopy
AbstractNine quillaic acid and five gypsogenin bisdesmosides were isolated from roots of Saponaria officinalis L. (Caryophyllaceae). Seven of the quillaic acid saponins possessed a 3-O-β-d-galactopyranosyl-(1 → 2)-[β-d-xylopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl unit, but differed from each other in oligosaccharide units linked to the C-28 ester. The five gypsogenin saponins isolated from the roots all possessed the 3-O-β-d-galactopyranosyl-(1 → 2)-[β-d-xylopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl unit, with their oligosaccharide units linked to the C-28 ester differing. Structures were elucidated by extensive 1D and 2D NMR spectroscopy and mass spectrometry. The saponins were evaluated for growth inhibitory activity in two human cancer cell lines and hemolytic activity in sheep red blood cells.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationNational Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
NPARC number21275538
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Record identifier797fbd14-e338-47cd-9fdf-aad79a07729a
Record created2015-07-14
Record modified2016-08-22
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