Hepatoprotective effect of Combretum quadrangulare and its constituents

Download
  1. Get@NRC: Hepatoprotective effect of Combretum quadrangulare and its constituents (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1248/bpb.23.456
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleBiological and Pharmaceutical Bulletin
ISSN0918-6158
1347-5215
Volume23
Issue4
Pages456460; # of pages: 5
SubjectCombretum quadrangulare; hepatoprotective effect; flavone, cycloartane-type triterpene; flavone C-glycoside
AbstractThe MeOH extract of leaves of Combretum quadrangulare showed significant hepatoprotective effect on D-galactosamin (D-GalN)/lipopolysaccharide (LPS)induced experimental liver injury in mice and on D-GalN/tumor necrosis factor-α (TNF-α)-induced cell death in primary cultured mouse hepatocytes. Phytochemical investigation led to the isolation of thirty cycloartane-type triterpenes together with betulinic acid, β-stitosterol, β-sitosterol glucoside, 4 flavones (34-37), and 3 flavone C-glucosides (38-40). These compounds showed various potencies of hepatoprotective effect on D-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes. Quadrangularol B (29), methyl quadrangularate I (33), kamatakenin (34), 5, 7, 4'-trihydroxy-3, 3'-dimethoxyflavone (35), 5, 4'-dihydroxy-3, 7, 3'-trimethoxyflavone (36) and isokaempferide (37) showed strong inhibitory effect on TNF-α-induced cell death with IC50 values of 34.3, 33.7, 13.3, 22.4, 13.4 and 22.8 μM, respectively, whereas clinically-used silibinin had an IC50 value of 39.6 μM and glycyrrhizin showed very weak inhibitory effect. Methyl quadarangularates A (30) and N (32), norquadrangularic acid B (31) and vitexin (40) also showed potent inhibition on TNF-α-induced cell death with IC50 values of 45.7, 89.3, 67.6 and 40.1 μM, respectively. The flavonoids and some of the cycloartane-type triterpenes appeared to be the hepatoprotective priniciples of the leaves of C. quadrangulare.
Publication date
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21275301
Export citationExport as RIS
Report a correctionReport a correction
Record identifier79d12ea4-384c-4443-8121-58d577a6b103
Record created2015-06-04
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)