Advances in high-field magnetic resonance spectroscopy in Alzheimer's disease

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DOIResolve DOI: http://doi.org/10.2174/1567205011666140302200312
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TypeArticle
Journal titleCurrent Alzheimer Research
ISSN1567-2050
Volume11
Issue4
Pages367388; # of pages: 22
Subject4 aminobutyric acid; glucose; glutamic acid; glutamine; glutathione; inositol; lactic acid; n acetylaspartylglutamic acid; taurine; aging; Alzheimer disease; disease course; information processing; magnetic field; Medline; metabolite; nuclear magnetic resonance spectroscopy; single voxel proton magnetic resonance spectroscopy
AbstractAlzheimer's disease (AD) affects several important molecules in brain metabolism. The resulting neurochemical changes can be quantified non-invasively in localized brain regions using in vivo single-voxel proton magnetic resonance spectroscopy (SV 1H MRS). Although the often heralded diagnostic potential of MRS in AD largely remains unfulfilled, more recent use of high magnetic fields has led to significantly improved signal-to-noise ratios and spectral resolutions, thereby allowing clinical applications with increased measurement reliability. The present article provides a comprehensive review of SV 1H MRS studies on AD at high magnetic fields (3.0 Tesla and above). This review suggests that patterned regional differences and longitudinal alterations in several neurometabolites are associated with clinically established AD. Changes in multiple metabolites are identifiable even at early stages of AD development. By combining information of neurochemicals in different brain regions revealing either pathological or compensatory changes, high field MRS can be evaluated in AD diagnosis and in the detection of treatment effects. To achieve this, standardization of data acquisition and analytical approaches is needed.
Publication date
PublisherBentham Science
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biodiagnostics; Medical Devices
Peer reviewedYes
NPARC number21272946
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Record identifier7b3b6685-a3f3-4990-9b9f-03a01730b472
Record created2014-12-03
Record modified2016-05-09
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