Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery

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Journal titleBiomaterials
Pages12401248; # of pages: 9
SubjectBreast tumor; Coherent anti-Stokes Raman; Magnetic nano-particles; Michael additions; Self assembled nanoparticles; Superparamagnetic iron oxide nanoparticles; Theranostics; Two-photon excited fluorescence; Addition reactions; Copolymers; Drug delivery; Grafts; Mammals; Nanomagnetics; Nanoparticles; Polyethylene oxides; Self assembly; Tumors; Polyethylene glycols; copolymer; doxorubicin; magnetic nanoparticle; nanocrystal; polyamidoamine; superparamagnetic iron oxide; animal experiment; animal model; animal tissue; aqueous solution; article; breast tumor; cancer chemotherapy; cancer inhibition; cell strain MCF 7; chemical structure; confocal laser microscopy; drug cytotoxicity; drug delivery system; drug release; fluorescence; heart; histology; human; human cell; hydrophobicity; in vitro study; in vivo study; kidney; liver; mouse; nanotechnology; nonhuman; nuclear magnetic resonance imaging; nude mouse; photon; polymerization; priority journal; synthesis; thermogravimetry; tumor growth; two photon excited fluorescence; Mus
AbstractWe report a reducible copolymer self-assembled with superparamagnetic iron oxide nanoparticles (SPIONs) to deliver doxorubicin (DOX) for cancer therapy. The copolymer of reducible polyamidoamine (rPAA) with poly(ethylene glycol)(PEG)/dodecyl amine graft was synthesized by Michael addition. rPAA@SPIONs were formed by the alkyl grafts of reducible copolymers intercalated with the oleic acid layer capped on the surface of magnetite nanocrystals. The intercalating area formed a reservoir for hydrophobic anti-cancer drug (DOX), whilst the PEG moiety in the copolymers helped the nanoparticle well-dispersible in aqueous solution. We employed two-photon excited fluorescence (TPEF) and coherent anti-Stokes Raman (CARS) to investigate drug delivery in intra-cellular structures of live cells, and used Vivaview® technique to show real-time inhibition efficacy of nanoparticles in live cells. rPAA@SPIONs present efficiently drug loading with reducible responsibility invitro tests. Finally, rPAA@SPIONs were tested in mice with xenograft MDA-MB-231 breast tumor though i.v. injection and inhibited tumor growth efficiently. MRI was used to monitor nanoparticles aggregation in tumor site. Histology and Prussian blue on kidney, liver, and heart in mice indicated that DOX/rPAA@SPIONs showed no significant toxicity for mice organs after 24 days treatment. © 2013 Elsevier Ltd.
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AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270757
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Record identifier7bcdf920-304d-4407-bcbd-2ff12e749b98
Record created2014-02-17
Record modified2016-05-09
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