Molecular structure of phosphatidylglycerol bilayers : fluid phase lipid areas and bilayer thicknesses as a function of temperature

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DOIResolve DOI: http://doi.org/10.1016/j.bpj.2011.11.2763
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TypeArticle
Proceedings titleBiophysical Journal
ConferenceBiophysical Society 56th Annual Meeting, 25-29 February 2012, San Diego, California, USA
ISSN0006-3495
Volume102
Issue3 Supplement 1
Pages504a
AbstractWe have determined bilayer structural parameters of commonly used phosphatidylglycerols (PGs) in the fluid phase, by simultaneously analyzing small-angle neutron and X-ray scattering data. We report the temperature dependence of bilayer parameters obtained using the scattering density profile (SDP) model, including the area per lipid and overall bilayer thickness, as well as various intrabilayer structural parameters (e.g. hydrocarbon region thickness). Lipid areas were found to be larger than their neutral phosphatidylcholine (PC) counterparts, which is likely due to electrostatic repulsion of PG headgroups. In general, PG and PC bilayers show a similar response to changes in temperature and chain length, but a differential effect is observed with regard to chain unsaturation: the inclusion of a double bond in a PG lipid results in a smaller change in bilayer area and thickness than for the corresponding PC lipid. The extrapolated molecular area of saturated PG lipids at infinite chain length is similar to that of PC and PE, indicating the pivotal role of the glycerol-carbonyl backbone in shaping the lipid-water interface.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
NPARC number21268046
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Record identifier7bda8bd7-242e-403b-a4f6-2b33cef57359
Record created2013-04-04
Record modified2016-05-09
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