Synthetic diversification of natural products : semi-synthesis and evaluation of triazole jadomycins

Download
  1. Get@NRC: Synthetic diversification of natural products : semi-synthesis and evaluation of triazole jadomycins (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1039/c2sc00663d
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleChemical Science
Volume3
Issue5
Pages16401644; # of pages: 5
AbstractGrowth of Streptomyces venezuelae ISP5230 with O-propargyl-L-serine led to the efficient production of an alkyne-containing jadomycin. The installed alkyne functionality provided a uniquely reactive handle within the natural product and was subsequently reacted with a series of azides to afford an eight-member library of jadomycin triazoles. The compounds were evaluated for their DNA cleavage, antibacterial and cytotoxic properties.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; Human Health Therapeutics; Aquatic and Crop Resource Development
Peer reviewedNo
NRC number54067
NPARC number21268176
Export citationExport as RIS
Report a correctionReport a correction
Record identifier7c8ec638-71b5-4e4b-ab9f-182f8b017c28
Record created2013-05-16
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)