Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines

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DOIResolve DOI: http://doi.org/10.1016/S0378-8741(02)00022-3
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TypeArticle
Journal titleJournal of Ethnopharmacology
ISSN0378-8741
Volume80
Issue1
Pages6773; # of pages: 7
SubjectPropolis; Antiproliferative activity; DPPH radical scavenging activity; Benzyl caffeate; Phenethyl caffeate; Cinnamyl caffeate
AbstractThe MeOH extract of the Netherlands propolis showed promising antiproliferative activity toward highly liver-metastatic murine colon 26-L5 carcinoma with an EC50 value of 3.5 μg/ml. Further, antiproliferative activity-guided purification of the MeOH extract led us to isolate four flavonoids (1–4), seven cinnamic acid derivatives (5–11) and two new glycerol derivatives (12, 13), whose structures were elucidated on the basis of spectral analysis. The isolated compounds were tested for their antiproliferative activity against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma and human lung A549 adenocarcinoma cell lines. The benzyl (9), phenethyl (10) and cinnamyl caffeates (11) possessed potent antiproliferative activities with EC50 values of 0.288, 1.76 and 0.114 μM, respectively, toward colon 26-L5 carcinoma. These caffeates were considered to be active constituents of the Netherlands propolis in their antiproliferative activity. The antioxidative activity of these caffeates may play an important role in their antiproliferative activities.
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LanguageEnglish
Peer reviewedYes
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NPARC number21274781
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Record identifier7fb87261-ba85-46f0-9862-e3df2e38faf1
Record created2015-04-08
Record modified2016-05-09
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