Comprehensive Analysis of Bacterial Risk Factors for the Development of Guillain-Barre Syndrome after Campylobacter jejuni Enteritis: J.Infect.Dis.

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TypeArticle
Journal titleJ.Infect.Dis.
Volume193
Issue4
Pages547555; # of pages: 9
Subjectanalysis; Antibodies; antibody; bacterial; biosynthesis; Campylobacter; Campylobacter jejuni; GANGLIOSIDE; Guillain-Barre Syndrome; lipooligosaccharide; MONOCLONAL-ANTIBODIES; MONOCLONAL-ANTIBODY; SEROTYPE; SEROTYPES; STRAIN; STRAINS; structure; Syndrome; Synthesis
AbstractBackground. Guillain-Barre syndrome (GBS), a postinfectious autoimmune-mediated neuropathy, is a serious complication after Campylobacter jejuni enteritis.Methods. To investigate the bacterial risk factors for developing GBS, genotypes, serotypes, and ganglioside mimics on lipo-oligosaccharide (LOS) were analyzed in C. jejuni strains from Japanese patients.Results. Strains from patients with GBS had LOS biosynthesis locus class A more frequently (72/106; 68%) than did strains from patients with enteritis (17/103; 17%). Class A strains predominantly were serotype HS:19 and had the cstII (Thr51) genotype; the latter is responsible for biosynthesis of GM1-like and GD1a-like LOSs. Both anti-GM1 and anti-GD1a monoclonal antibodies regularly bound to class A LOSs, whereas no or either antibody bound to other LOS locus classes. Mass-spectrometric analysis showed that a class A strain carried GD1a-like LOS as well as GM1-like LOS. Logistic regression analysis showed that serotype HS:19 and the class A locus were predictive of the development of GBS.Conclusions. The high frequency of the class A locus in GBS-associated strains, which was recently reported in Europe, provides the first GBS-related C. jejuni characteristic that is common to strains from Asia and Europe. The class A locus and serotype HS:19 seem to be linked to cstII polymorphism, resulting in promotion of both GM1-like and GD1a-like structure synthesis on LOS and, consequently, an increase in the risk of producing antiganglioside autoantibodies and developing GBS
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberKOGA2006
NPARC number9364053
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Record identifier824e2a90-2a4f-4ea7-8917-0e5146ec6c77
Record created2009-07-10
Record modified2016-05-09
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