Absorption and transport of deuterium-substituted 2 R,4′R,8′R-α-tocopherol in human lipoproteins

Download
  1. Get@NRC: Absorption and transport of deuterium-substituted 2 R,4′R,8′R-α-tocopherol in human lipoproteins (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1007/BF02536223
AuthorSearch for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleLipids
ISSN0024-4201
Volume23
Issue8
Pages791797; # of pages: 7
Subjectalpha tocopherol; deuterium; lipoprotein; very low density lipoprotein; human; vitamin absorption; Chylomicrons; Deuterium; Human; Lipoproteins; Male; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Ultracentrifugation; Vitamin E
AbstractOral administration of a single dose of tri- or hexadeuterium substituted 2 R,4′R,8′R-α-tocopheryl acetate (d3- or d6-α-T-Ac) to humans was used to follow the absorption and transport of vitamin E in plasma lipoproteins. Three hr after oral administration of d3-α-T-Ac (15 mg) to 2 subjects, plasma levels of d3-α-T were detectable; these increased up to 10 hr, reached a plateau at 24 hr, then decreased. Following administration of d6-α-T-Ac (15-16 mg) to 2 subjects, the percentage of deuterated tocopherol relative to the total tocopherol in chylomicrons increased more rapidly than the corresponding percentage in whole plasma. Chylomicrons and plasma lipoproteins were isolated from 2 additional subjects following administration of d3-α-T-Ac (140 or 60 mg). The percentage of deuterated tocopherol relative to the total tocopherol increased most rapidly in chylomicrons, then in very low density lipoproteins (VLDL), followed by essentially identical increases in low and high density lipoproteins (LDL and HDL, respectively) and lastly, in the red blood cells. This pattern of appearance of deuterated tocopherol is consistent with the concept that newly absorbed vitamin E is secreted by the intestine into chylomicrons; subsequently, chylomicron remnants are taken up by the liver from which the vitamin E is secreted in VLDL. The metabolism of VLDL in the circulation results in the simultaneous delivery of vitamin E into LDL and HDL. © 1988 American Oil Chemists' Society.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276797
Export citationExport as RIS
Report a correctionReport a correction
Record identifier8297906c-5ddb-4333-b5f2-03ae79cf8978
Record created2015-10-13
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)