Hyperforin modifies neuronal membrane properties in vivo

Download
  1. Get@NRC: Hyperforin modifies neuronal membrane properties in vivo (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/j.neulet.2004.04.053
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleNeuroscience Letters
Volume367
Issue2
Pages139143; # of pages: 5
SubjectHypericum perforatum; St. John?s Wort; hyperforin; brain; membrane; fluidity; HPLC; MS
AbstractHyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the physical state of neuronal membranes. Accordingly, we tested the effects of SJW extract and of hyperforin on the properties of murine brain membrane fluidity. Oral administration of SJW extract and of hyperforin sodium salt results in significant hyperforin brain levels. Treatment of mice with hyperforin leads to decreased annular- and bulk fluidity and increased acyl-chain flexibility of brain membranes. All hyperforin related changes of membrane properties were significantly correlated with the corresponding hyperforin brain levels. Our data emphasises a membrane interaction of hyperforin that possibly contributes to its pharmacological effects.
Publication date
Copyright noticeCopyright © 2004 Elsevier Ireland Ltd. All rights reserved.
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada
Peer reviewedYes
NRC number1684
NPARC number3538168
Export citationExport as RIS
Report a correctionReport a correction
Record identifier82a759f8-4a3e-4b77-a26d-c0a5762ba258
Record created2009-03-01
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)