Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts

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DOIResolve DOI: http://doi.org/10.​1152/​ajpheart.​01082.​2008
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TypeArticle
Journal titleAmerican Journal of Physiology: Heart and Circulation Physiology
Volume297
Issue3
PagesH1020H1031
SubjectAnimals; biological markers; capillaries; capillaries physiology; cardiac; cardiac cytology
AbstractThis study assessed the potential therapeutic efficacy of adipose-derived stem cells (ASCs) on infarcted hearts. Myocardial infarction was induced in rat hearts by occlusion of the left anterior descending artery (LAD). One week after LAD occlusion, the rats were divided into three groups and subjected to transplantation of ASCs or transplantation of cell culture medium (CCM) or remained untreated. During a 1-mo recovery period, magnetic resonance imaging showed that the ASC-treated hearts had a significantly greater left ventricular (LV) ejection fraction and LV wall thickening than did the CCM-treated and untreated hearts. The capillary density in infarct border zone was significantly higher in the ASC-treated hearts than in the CCM-treated and untreated hearts. However, only 0.5% of the ASCs recovered from the ASC-treated hearts were stained positive for cardiac-specific fibril proteins. It was also found that ASCs under a normal culture condition secreted three cardiac protective growth factors: vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor-1. Results of this study suggest that ASCs were able to improve cardiac function of infarcted rat hearts. Paracrine effect may be the mechanism underlying the improved cardiac function and increased capillary density.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number20015565
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Record identifier84876b93-7838-4218-b54e-f04e363ff889
Record created2012-05-26
Record modified2016-05-09
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