Adenosine monophosphate forms ordered arrays in multilamellar lipid matrices: insights into assembly of nucleic acid for primitive life

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DOIResolve DOI: http://doi.org/10.1371/journal.pone.0062810
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TypeArticle
Journal titlePLoS ONE
ISSN1932-6203
Volume8
Issue5
Article numbere62810
Subjectadenosine phosphate; dimyristoylphosphatidylcholine; nucleic acid; phosphate; ribose; Bragg peak; crystal structure; mathematical phenomena; molecular biology; molecule lateral organization; multilamellar phospholipid matrix; nucleic acid assembly; nucleic acid structure; nucleic acid structure, metabolism and function; phospholipid bilayer; polymerization; radiation scattering; structure analysis
AbstractA fundamental question of biology is how nucleic acids first assembled and then were incorporated into the earliest forms of cellular life 4 billion years ago. The polymerization of nucleotides is a condensation reaction in which phosphodiester bonds are formed. This reaction cannot occur in aqueous solutions, but guided polymerization in an anhydrous lipid environment could promote a non-enzymatic condensation reaction in which oligomers of single stranded nucleic acids are synthesized. We used X-ray scattering to investigate 5′-adenosine monophosphate (AMP) molecules captured in a multilamellar phospholipid matrix composed of dimyristoylphosphatidylcholine. Bragg peaks corresponding to the lateral organization of the confined AMP molecules were observed. Instead of forming a random array, the AMP molecules are highly entangled, with the phosphate and ribose groups in close proximity. This structure may facilitate polymerization of the nucleotides into RNA-like polymers.
Publication date
PublisherPLOS
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21269863
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Record identifier85156115-3a21-4196-8cce-cbcdf7c9893c
Record created2013-12-13
Record modified2016-07-19
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