A solid-phase, library synthesis of natural-product-like derivatives from an enantiomerically pure tetrahydroquinoline scaffold

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DOIResolve DOI: http://doi.org/10.1021/cc030026x
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TypeArticle
Journal titleJournal of Combinatorial Chemistry
ISSN1520-4766
Volume6
Issue1
Pages7377; # of pages: 5
AbstractWith the goal of developing a library synthesis of tetrahydroquinoline-derived natural-product-like small molecules, a practical synthesis of enantiomerically pure tetrahydroquinoline scaffold was achieved. An asymmetric aminohydroxylation reaction was the key step in this strategy. This scaffold was further immobilized onto the solid support for the library generation. The library was obtained from three diversity sites: (i) acylation of the hydroxyl group (R₁), (ii) coupling of the Fmoc-protected amino acid to the amino group (R₂), and (iii) amidation of the N-terminal amine group (R₃).
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier18517171
NPARC number12327924
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Record identifier86bfff71-810c-4b38-8c24-8cef4e496404
Record created2009-09-10
Record modified2016-05-09
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