Design and synthesis of analogs of vitamin E : Antiproliferative activity against human breast adenocarcinoma cells

Download
  1. (PDF, 495 KB)
  2. Get@NRC: Design and synthesis of analogs of vitamin E : Antiproliferative activity against human breast adenocarcinoma cells (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/S0960-894X(98)00438-7
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleBioorganic & Medicinal Chemistry Letters
Volume8
Issue18
Pages24332438; # of pages: 6
AbstractAnalogs of [alpha]-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common synthon, rac-Trolox (14) and are soluble/miscible at physiological pH. Compounds 4, 8, and 9 were found to have antiproliferative activity at micromolar concentrations.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
NPARC number12327322
Export citationExport as RIS
Report a correctionReport a correction
Record identifier8843141c-6dc4-4211-bec3-3cccb85fbbb9
Record created2009-09-10
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)