Recognition and Selective Transport of Nucleic Acid Components through Molecularly Imprinted Polymeric Membranes

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DOIResolve DOI: http://doi.org/10.1002/1439-2054(20010101)286:1<52::AID-MAME52>3.0.CO;2-R
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TypeArticle
Journal titleMacromolecular Materials and Engineering
Volume286
Issue1
Pages5259; # of pages: 8
AbstractTo induce ldquomolecular memoryrdquo in a membrane substrate at the same time that the membrane was prepared from its polymer solution, an alternative molecular imprinting technique was applied. Upon membrane formation, a ldquomolecular memoryrdquo of the imprint molecule is retained by the formed membrane that recognizes or favors interaction with print molecule analogues. In the present study, polystyrene resin bearing a tetrapeptide derivative, a derivative of natural polymer, and an entirely non-chiral synthetic polymer were adopted as candidate materials to form molecular recognition sites. 9-Ethyladenine was adopted as a print molecule. These molecularly imprinted polymeric membranes recognized and adsorbed adenosine (As), which is an analogue of the print molecule, in preference to guanosine (Gs) from As/Gs mixtures. However Gs was permeated in preference to As contrary to adsorption selectivity, possibly because of the relatively high affinity between As and the membrane.
Publication date
AffiliationNational Research Council Canada; NRC Institute for Chemical Process and Environmental Technology
Peer reviewedNo
NPARC number12330226
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Record identifier8ac2080b-eb2d-47c4-86ae-386671c01d9c
Record created2009-09-10
Record modified2016-05-09
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