Ceramide-enriched microdomains in planar membranes

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DOIResolve DOI: http://doi.org/10.1016/j.cocis.2010.06.003
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Journal titleCurrent Opinion in Colloid & Interface Science
Pages489498; # of pages: 10
SubjectCeramide; Monolayers; Supported bilayers; Microdomains; Sphingomyelinase
AbstractCeramide has a large effect on the properties of biological membranes, increasing lipid order and promoting lateral phase separation, and plays an important role in cell signaling. This review provides an overview of recent studies of the effects of direct ceramide incorporation and enzymatic ceramide generation on planar supported membranes, including lipid monolayers and supported lipid bilayers. Recent studies have focused on understanding the nucleation, growth and morphology of ceramide gel domains, characterizing the properties of ceramide-rich membrane phases and investigating the effects of ceramide on phase-separated membranes with co-existing liquid-ordered and fluid phases, as models for cellular membranes.
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AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedYes
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This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number17178732
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Record identifier8bd8728b-b3cd-469e-b163-741084bb979b
Record created2011-03-15
Record modified2016-05-09
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