Eleven novel diarylheptanoids and two unusual diarylheptanoid derivatives from the seeds of Alpinia blepharocalyx

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DOIResolve DOI: http://doi.org/10.1021/np000492t
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume64
Issue2
Pages208213; # of pages: 6
AbstractAn EtOH extract of the seeds of Alpinia blepharocalyx afforded 11 novel diarylheptanoids, named deoxycalyxin A (1), epicalyxin F (2), calyxin K (3), epicalyxin K (4), calyxin I (5), epicalyxin I (6), calyxin J (7), epicalyxin J (8), and calyxin L (9), an epimeric mixture of calyxin M (10) and epicalyxin M (11), and two unusual diarylheptanoid derivatives, named neocalyxins A (12) and B (13), together with four known calyxins, calyxins A (14), F (15), E (16), and G (17). Structures were elucidated by spectroscopic techniques including 2D NMR spectroscopy. All compounds were examined for cytotoxicity toward murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cells. Diarylheptanoids 2, 3, and 5 were cytotoxic against both cell lines, while 4 and 6-8 were cytotoxic against human fibrosarcoma cells.
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LanguageEnglish
Peer reviewedYes
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NPARC number21274815
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Record identifier8bf43146-592a-44e1-b5cb-a869651f0518
Record created2015-04-13
Record modified2016-05-09
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