The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an affective vaccine adjuvant

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DOIResolve DOI: http://doi.org/10.1016/j.vaccine.2010.02.081
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TypeArticle
Journal titleVaccine
Volume28
Issue18
Pages30803085; # of pages: 6
Abstract3' , 5'-Cyclic diguanylic acid (c-di-GMP) is a bacterial intracellular signaling molecule that plays a crucial role in the regulation of bacterial motility, adhesion, cell-to-cell communication, exopolysaccharide synthesis, biofilm formation and virulence. The recent finding that c-di-GMP can act as a danger signal on eukaryotic cells has prompted the study of the immunostimulatory and immunomodulatory properties of c-di-GMP in an effort to determine whether c-di-GMP might be further developed as a potential vaccine adjuvant. In this review, we discussed the recent in vitro and in vivo studies of the immunostimulatory properties of c-di-GMP and the progress that has been made in the preclinical development of c-di-GMP as a potential vaccine adjuvant for systemic and mucosal vaccination.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17652982
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Record identifier8cc9850f-e1e0-4a09-8f66-8c37b9a35e84
Record created2011-04-01
Record modified2016-05-09
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