Determination of chemical purity and isotopic composition of natural and carbon-13-labeled arsenobetaine bromide standards by quantitative 1H-NMR

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DOIResolve DOI: http://doi.org/10.1007/s00216-016-9827-y
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TypeArticle
Journal titleAnalytical and Bioanalytical Chemistry
ISSN1618-2642
1618-2650
Volume49
Issue8
Pages681691
SubjectIsotope ratio measurements; Arsenobetaine; Standard; Certified reference material
AbstractIn this study, we report the characterization of three arsenobetaine-certified reference materials by quantitative NMR. We have synthesized an arsenobetaine bromide high-purity standard of natural isotopic composition (ABET-1) and two carbon-13-labeled isotopic standards (BBET-1 and CBET-1). Assignments of the chemical purity and isotopic composition are not trivial in the case of arsenobetaine, and in this study we utilized quantitative 1H-NMR techniques for the determination of the mass fractions (chemical purity). The isotopic purity of all three standards was also assessed by NMR from the carbon-13 satellite signals. The standards are non-hygroscopic, highpurity (ca. 0.99 g/g), and the carbon-13 enrichment for both isotopic standards is x(13C) ≈ 0.99. These standards are designed for use as primary calibrators for mass spectrometric determination of arsenobetaine in environmental samples.
Publication date
PublisherSpringer Verlag
LanguageEnglish
AffiliationMeasurement Science and Standards; Security and Disruptive Technologies; Energy, Mining and Environment; National Research Council Canada
Peer reviewedYes
NPARC number23000646
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Record identifier8cfca93b-ee4b-4828-8933-b2d464f06a9b
Record created2016-08-17
Record modified2016-08-17
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