Performance analysis of a swept-source optical coherence tomography system with a quadrature interferometer and optical amplification

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DOIResolve DOI: http://doi.org/10.1016/j.optcom.2011.01.016
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TypeArticle
Journal titleOptics Communications
Volume284
Pages26222627; # of pages: 5
SubjectOptical coherence tomography; Quadrature interferometer; Semiconductor optical amplifier; Medical; Biological imaging
AbstractA performance analysis of signal to noise ratio for an optical coherence tomography system with quadrature detection and a semiconductor optical amplifier in the sample arm is discussed. The results are compared and discussed in relation to a conventional OCT system (without optical amplification). An increase of the signal to noise ratio up to 14 dB at a depth of 0.5 mmis obtained compared to the system without the optical amplifier. Overall, an improvement was demonstrated for signal coming from deeper regions within the samples. Arterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using this system. Improvement of signal to noise ratio increases the penetration depth possible for OCT images, from 1 mm to 2 mm within the vessel wall of an artery. Preliminary results show that vulnerable plaque with fibrous cap, macrophage accumulations and calcification in the arterial tissue are measurable with this OCT system.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Microstructural Sciences; NRC Institute for Biodiagnostics
Peer reviewedYes
NPARC number17400968
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Record identifier8d396559-d11d-4095-b70e-facc2bbe9815
Record created2011-03-26
Record modified2016-05-09
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