Influence of cholesterol on the bilayer properties of monounsaturated phosphatidylcholine unilamellar vesicles

Download
  1. Get@NRC: Influence of cholesterol on the bilayer properties of monounsaturated phosphatidylcholine unilamellar vesicles (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1140/epje/i2007-10202-8
AuthorSearch for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleThe European Physical Journal E - Soft Matter
Volume23
Issue3
Pages247254; # of pages: 8
AbstractThe influence of cholesterol on the structure of unilamellar-vesicle (ULV) phospholipid bilayers is studied using small-angle neutron scattering. ULVs made up of short-, mid- and long-chain monounsaturated phospholipids (diCn :1PC, n = 14 , 18, 22, respectively) are examined over a range (0-45mol %) of cholesterol concentrations. Cholesterol's effect on bilayer structure is characterized through changes to the lipid's transmembrane thickness, lateral area and headgroup hydration. For all three lipids, analysis of the experimental data shows that the addition of cholesterol results in a monotonic increase of these parameters. In the case of the short- and mid-chain lipids, this is an expected result, however, such a finding was unexpected for the long-chain lipid. This implies that cholesterol has a pronounced effect on the lipid's hydrocarbon chain organization.
Publication date
AffiliationNational Research Council Canada; NRC Canadian Neutron Beam Centre
Peer reviewedNo
NPARC number12338655
Export citationExport as RIS
Report a correctionReport a correction
Record identifier8e38606f-6ae8-462d-b922-74200ee4325a
Record created2009-09-10
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)