A short route to L-iduronic acid building blocks for the syntheses of heparin-like disaccharides

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DOIResolve DOI: http://doi.org/10.1016/j.tetlet.2003.08.092
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TypeArticle
Journal titleTetrahedron Letters
Volume44
Issue42
Pages77677770; # of pages: 4
Subjectglycosylations; carbohydrates; heparin; disaccharides
AbstractThe effective preparation of differentially protected l-iduronic acid derivatives, as building blocks for the synthesis of heparin-like oligosaccharides, is described in less than nine steps starting from readily available 1,2-O-isopropylidene-6,3-d-glucuronolactone. The pivaloyl group was used as a permanent protecting group of hydroxyl groups. Two heparin-like disaccharides with different sulfation pattern have been prepared by using these l-iduronic acid building blocks.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberKE2003
NPARC number9364752
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Record identifier8fc6cd5d-4dff-4d30-9fdb-3ff68534543e
Record created2009-07-10
Record modified2016-05-09
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