The effect of coating of Fe3o4/silica core/shell nanoparticles on T2 relaxation time at 9.4 T

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DOIResolve DOI: http://doi.org/10.1051/epjap/2011100244
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TypeArticle
Journal titleThe European Physical Journal Applied Physics
Volume55
Issue1
Pages10401
AbstractMagnetic Resonance Imaging (MRI) that provides superior soft tissue contrast is commonly used for diagnosis of many diseases. However specificity of MRI cancer diagnosis can be further increased by application of target contrast agents comprising superparamagnetic nanoparticles (NPs) synthesised with biological objects, which deliver the contrast to the specific cancer cells. These superparamagnetic NPs shorten T2 relaxation time thus change contrast to noise ratio for tumor tissues. Therefore the impact of Fe3O4 size and silica coating for Fe3O4/silica core/shell superparamagnetic nanoparticles (NPs) on T2 relaxation time was studied at 9.4 T. The magnetic resonance imaging (MRI) studies were performed using homogenous agar solution of NPs. Naked Fe3O4NPs with a mean core diameter of 10.0 ± 1.3 (mean ± SD), 15.0 ± 2.5 and 20.0 ± 0.9 nm were analyzed. Silica coated Fe3O4 NPs with core size of 10.0 ± 1.3 nm and the shell thickness of 16.7 ± 1.8, 25.3 ± 2.7 and 33.9 ± 4.0 nm were also investigated. The T2 values of agar solutions with different NPs were calculated using a single slice multi echo method and single exponential fitting of the echo train. The measurements showed linear correlation between T2 and Fe3O4 core diameter as well as shell thickness. Silica coating, while improving functionalization and potentially reducing toxicity of NPs, decreases the impact of the magnetic core on T2, thus decreasing MRI contrast efficacy.
Publication date
PublisherCambridge University Press
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; NRC Industrial Materials Institute; Medical Devices; National Research Council Canada
NoteErratum published in volume 56, issue 1, page 11401, October 2011. DOI: 10.1051/epjap/2011110344
Peer reviewedYes
NPARC number19689649
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Record identifier8fffcef6-3081-4494-bd08-3b899a2ab390
Record created2012-03-22
Record modified2016-05-09
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