Association of Gap-43 (neuromodulin) with microtubule-associated protein MAP-2 in neuronal cells: Biochem.Biophys Res.Commun.

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TypeArticle
Journal titleBiochem.Biophys Res.Commun.
Volume371
Issue4
Pages679683; # of pages: 5
SubjectAdult; Amino Acid Sequence; analysis; Animals; Brain; Canada; cell; CELLS; Cells,Cultured; chemistry; GAP-43 Protein; Immunoprecipitation; interaction; metabolism; Microtubule-Associated Proteins; Molecular Sequence Data; Neurons; protein; Protein Interaction Mapping; Proteins; Rats
AbstractGap-43 (B-50, neuromodulin) is a presynaptic protein implicated in axonal growth, neuronal differentiation, plasticity, and regeneration. Its activities are regulated by its dynamic interactions with various neuronal proteins, including actin and brain spectrin. Recently we have shown that Gap-43 co-localizes with an axonal protein DPYSL-3 in primary cortical neurons. In the present study we provide evidence that Gap-43 co-localizes and potentially interacts with microtubule-associated protein MAP-2 in adult and fetal rat brain, as well as in primary neuronal cultures. Our studies suggest that this interaction may be developmentally regulated
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberCHAKRAVARTHY2008
NPARC number9358348
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Record identifier91814ebb-d7ee-44e3-87c6-5072fb2a4bca
Record created2009-07-10
Record modified2016-05-09
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