Effects of charge density and thermal history on the morphologies of spontaneously formed unilamellar vesicles

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DOIResolve DOI: http://doi.org/10.1021/jp9106684
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TypeArticle
Journal titleThe journal of physical chemistry. B
Volume114
Issue17
Pages57295735; # of pages: 7
AbstractA phospholipid mixture consisting of dimyristoyl phosphatidylcholine (DMPC), dihexanoyl phosphatidylcholine (DHPC), and the negatively charged dimyristoyl phosphatidylglycerol (DMPG) lipid is found to spontaneously form uniform-size unilamellar vesicles (ULVs). Small angle neutron scattering (SANS) is used to examine ULV size as a function of net charge, dilution, and thermal history. It shows that ULVs only exist within a narrow window of charge densities, where larger size ULVs can be obtained at a lower charge density through slow temperature annealing. There is also a 6-fold change in the size of low polydispersity ULVs, confirming a previously proposed model for spontaneously forming ULVs [Nieh, M.-P. et al. Langmuir 2005, 21, 6656]. Finally, the stability of these ULVs was confirmed through a series of high temperature dilution experiments, further making the case that these nanoparticles can be used as carriers for drugs and contrast imaging agents.
Publication date
LanguageEnglish
AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
NPARC number16984546
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Record identifier927be595-28f0-480b-94e3-7e977e983190
Record created2011-03-08
Record modified2016-05-09
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