Competitive interference between influenza viral strains

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Journal titleThe Canadian Applied Mathematics Quarterly
Pages309316; # of pages: 8
Subjectinfluenza; viral strains; cross-immunity; epidemic models
AbstractWe propose a modelling framework for investigating the dynamics of competition between immunologically-related influenza viral strains in the absence of pre-existing immunity. Assuming that the host immune system will mount partial protection (cross-immunity) against one strain by virtue of having interacted with the other through exposure, we discuss the conditions for the occurrence of two distinct waves of infection during a single epidemic episode. Numerical simulations are presented to illustrate the possibility of infection waves with respect to the protection level induced by the first strain, and the time-lag for evolving the second strain. We propose directions for future work that involves extension of the model to include vaccination.
Publication date
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number19726585
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Record identifier936b9860-8285-4df3-ae4a-8a4558fc244b
Record created2012-03-28
Record modified2016-05-09
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