Sensitivity to white matter fMRI activation increases with field strength

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DOIResolve DOI: http://doi.org/10.1371/journal.pone.0058130
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TypeArticle
Journal titlePLoS ONE
ISSN1932-6203
Volume8
Issue3
Article numbere58130
Subjectadult; article; controlled study; female; field strength; functional magnetic resonance imaging; gray matter; human; human experiment; image analysis; male; motor performance; normal human; radiological parameters; sensorimotor cortex; signal noise ratio; task performance; white matter
AbstractFunctional magnetic resonance imaging (fMRI) activation in white matter is controversial. Given that many of the studies that report fMRI activation in white matter used high field MRI systems, we investigated the field strength dependence of sensitivity to white matter fMRI activation. In addition, we evaluated the temporal signal to noise ratio (tSNR) of the different tissue types as a function of field strength. Data were acquired during a motor task (finger tapping) at 1.5 T and 4 T. Group and individual level activation results were considered in both the sensorimotor cortex and the posterior limb of the internal capsule. We found that sensitivity increases associated with field strength were greater for white matter than gray matter. The analysis of tSNR suggested that white matter might be less susceptible to increases in physiological noise related to increased field strength. We therefore conclude that high field MRI may be particularly advantageous for fMRI studies aimed at investigating activation in both gray and white matter. © 2013 Mazerolle et al.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biodiagnostics (IBD-IBD)
Peer reviewedYes
NPARC number21269637
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Record identifier94693025-f576-4938-8fda-31d7f2f6b6fb
Record created2013-12-13
Record modified2016-05-09
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