NIR initiated and pH sensitive single-wall carbon nanotubes for doxorubicin intracellular delivery

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DOIResolve DOI: http://doi.org/10.1039/c3tb21362e
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TypeArticle
Journal titleJournal of Materials Chemistry B
ISSN2050-7518
Volume2
Issue9
Pages11251135; # of pages: 11
AbstractIn this work, we synthesized a pH sensitive poly(ethylene glycol)-doxorubicin (PEG-DOX) on single-wall carbon nanotubes (SWNTs). Using multimodal nonlinear optical imaging microscopy, we found that low power (1 mW cm-2) near-infrared radiation can initiate prodrug burst release from the carbon nanotubes in seconds. The successful SWNTs capping with PEG-DOX (denoted PEG-DOX@SWNT) was determined by transmission electron microscopy and FTIR results. The in vitro release of DOX from the PEG-DOX@SWNT was evaluated upon changes of pH values and NIR treating time. The cytotoxicity of the PEG-DOX@SWNT was also evaluated. This dual-sensitive delivery system based on SWNTs provides a facile approach to promote drug release and kill cancer cells.
Publication date
PublisherRoyal Society of Chemistry
LanguageEnglish
AffiliationNational Research Council Canada; Medical Devices
Peer reviewedYes
NPARC number21272775
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Record identifier95298f71-c9da-47df-8dd0-a46861557c1b
Record created2014-12-03
Record modified2016-05-09
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