Development of a MRI phantom to emulate the relaxation times of the neonatal brain at 3 Tesla

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Proceedings titleProceedings of the International Society for Magnetic Resonance in Medicine
Conference15th Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine, May 19-25, Berlin Germany
AbstractPrematurity greatly increases the risk of neurological impairment in newborn infants. Magnetic resonance imaging (MRI) provides powerful techniques for non-invasively investigating the impact of premature birth on early brain development. Experimental testing of MRI techniques on human nenonates is not ethically appropriate. Our previous work has shown that techniques used for brain imaging in adults are not optimal for neonates. Therefore, there is a crucial need for phantoms that can mimic MRI properties of the neonatal brain. Polyvinyl alcohol cryogel (PVA-C) has been investigated as a MRI phantom material for the adult brain. Our previous work showed that MRI relaxation times (T1 and T2) of 6-15% PVA-C were lower than those reported for neonatal white matter at 2.30 Tesla. The objective of this study was to investigate the relationship between PVA-C relation times and temperature to determine if sufficiently long relaxation times could be obtained by increasing temperature.
Publication date
AffiliationNRC Industrial Materials Institute; National Research Council Canada
Peer reviewedYes
NPARC number21274310
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Record identifier96c53db6-bff3-4389-8739-25f797943f2d
Record created2015-03-09
Record modified2016-05-09
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