Characterization of the alkaloids in goldenseal (Hydrastis canadensis) root by high resolution Orbitrap LC-MSn

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DOIResolve DOI: http://doi.org/10.1007/s00216-012-6539-9
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TypeArticle
Journal titleAnalytical and Bioanalytical Chemistry
ISSN1618-2642
1618-2650
Volume405
Issue13
Pages44874498; # of pages: 12
SubjectHydrastis canadensis; alkaloid; structural characterization; LC-ESI-MSn
AbstractLiquid chromatography coupled to multistage mass spectrometry (LC-MSn) is being used increasingly in pharmaceutical research and for quality control in herbal medicines because of its superior sensitivity and selectivity. In this study, a rapid, high-resolution liquid chromatography-mass spectrometry (LC-MSn) method was developed to separate and identify alkaloids in the root extract of goldenseal, which is one of the 20 most popular herbal supplements used worldwide. In total, 28 alkaloids were separated and characterized including one novel compound and 21 identified, or tentatively identified, for the first time in goldenseal. The current high-resolution LC-MSn method provides a rapid and definitive means of profiling the composition of goldenseal root and will provide a useful tool in understanding the bioactivity of this medicinal plant.
Publication date
PublisherSpringer
LanguageEnglish
AffiliationMeasurement Science and Standards; National Research Council Canada
Peer reviewedYes
Identifier6539
NPARC number21268289
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Record identifier9721728d-c3cb-4c8c-9a70-0a675af99e53
Record created2013-06-13
Record modified2016-05-09
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