Graphene versus multi-walled carbon nanotubes for electrochemical glucose biosensing

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DOIResolve DOI: http://doi.org/10.3390/ma6031011
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TypeArticle
Journal titleMaterials
ISSN1996-1944
Volume6
Issue3
Pages10111027; # of pages: 17
Subject3-aminopropyltriethoxysilane; Direct electron transfer; Electrochemical glucose sensors; Glassy carbon electrodes; Glucose oxidases (GOx); Interfering substances; Pathological level; Pathophysiological; Glass membrane electrodes; Glucose; Glucose oxidase; Glucose sensors; Metabolites; Multiwalled carbon nanotubes (MWCN); Graphene
AbstractA simple procedure was developed for the fabrication of electrochemical glucose biosensors using glucose oxidase (GOx), with graphene or multi-walled carbon nanotubes (MWCNTs). Graphene and MWCNTs were dispersed in 0.25% 3-aminopropyltriethoxysilane (APTES) and drop cast on 1% KOH-pre-treated glassy carbon electrodes (GCEs). The EDC (1-ethyl-(3-dimethylaminopropyl) carbodiimide)-activated GOx was then bound covalently on the graphene- or MWCNT-modified GCE. Both the graphene- and MWCNT-based biosensors detected the entire pathophysiological range of blood glucose in humans, 1.4-27.9 mM. However, the direct electron transfer (DET) between GOx and the modified GCE's surface was only observed for the MWCNT-based biosensor. The MWCNT-based glucose biosensor also provided over a four-fold higher current signal than its graphene counterpart. Several interfering substances, including drug metabolites, provoked negligible interference at pathological levels for both the MWCNT- and graphene-based biosensors. However, the former was more prone to interfering substances and drug metabolites at extremely pathological concentrations than its graphene counterpart. © 2013 by the authors.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270620
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Record identifier99416130-3392-4976-8d08-922d691f53a7
Record created2014-02-17
Record modified2016-05-09
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