Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour

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DOIResolve DOI: http://doi.org/10.1042/bj2500247
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TypeArticle
Journal titleBiochemical Journal
ISSN0264-6021
Volume250
Issue1
Pages247252; # of pages: 6
Subjectreduced nicotinamide adenine dinucleotide phosphate; reduced nicotinamide adenine dinucleotide phosphate ferrihemoprotein reductase; animal cell; gamma radiation; lipid peroxidation; liver; liver cell carcinoma; rat; 7-Alkoxycoumarin O-Dealkylase; Animal; Cell Division; Fatty Acids; Gamma Rays; In Vitro; Lipid Peroxides; Liver; Liver Neoplasms, Experimental; Male; Malondialdehyde; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxygenases; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Vitamin E
AbstractReduced rates of lipid peroxidation have been observed in Yoshida hepatoma cells and microsomes when compared with appropriate control tissue (normal rat liver) under the same pro-oxidant conditions. The pro-oxidant conditions used were incubation with NADPH + ADP + iron or ascorbate + iron or exposure to γ-irradiation. As previously shown with the Novikoff hepatoma, the relative concentrations of α-tocopherol and polyunsaturated fatty acids are important in conferring resistance to lipid peroxidation in the Yoshida hepatoma. Furthermore, NADPH-cytochrome P-450 electron transport chain, which are involved in the initiation and propagation of certain types of lipid peroxidation, are found at very much reduced levels in the Yoshida hepatoma. The relative importance of these aberrations are discussed.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276578
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Record identifier9962a6c5-70de-4084-a090-1332876ee14d
Record created2015-10-13
Record modified2016-05-09
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