In Vitro and in Vivo biological activities of iron chelators and gallium nitrate against Acinetobacter baumannii

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DOIResolve DOI: http://doi.org/10.1128/AAC.00778-12
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TypeArticle
Journal titleAntimicrobial Agents and Chemotherapy
ISSN0066-4804
Volume56
Issue10
Pages53975400; # of pages: 4
Subject2,2' bipyridine; chelating agent; gallium nitrate; transferrin; Acinetobacter baumannii; animal experiment; article; bacterial growth; bacterial load; bacteriostasis; controlled study; growth inhibition; in vitro study; in vivo study; iron metabolism; iron restriction; mouse; nonhuman; priority journal; 2,2'-Dipyridyl; Acinetobacter baumannii; Acinetobacter Infections; Animals; Gallium; Iron Chelating Agents; Mice; Transferrin
AbstractWe investigated the ability of compounds interfering with iron metabolism to inhibit the growth of Acinetobacter baumannii. Iron restriction with transferrin or 2,2-bipyridyl significantly inhibited A. baumannii growth in vitro. Gallium nitrate alone was moderately effective at reducing A. baumannii growth but became bacteriostatic in the presence of serum or transferrin. More importantly, gallium nitrate treatment reduced lung bacterial burdens in mice. The use of gallium-based therapies shows promise for the control of multidrug-resistant A. baumannii. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Human Health Therapeutics (HHT-TSH)
Peer reviewedYes
NPARC number21269459
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Record identifier9977cd26-d796-4047-baf1-b7d2ea873ed0
Record created2013-12-12
Record modified2016-05-09
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