Structural analysis of the lipopolysaccharide derived core oligosaccharides of Actinobacillus pleuropneumoniae serotypes 1, 2, 5a and the genome strain 5b

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DOIResolve DOI: http://doi.org/10.1016/j.carres.2004.04.019
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TypeArticle
Journal titleCarbohydrate Research
Volume339
Issue11
Pages19731984; # of pages: 12
AbstractThe structures of the core oligosaccharides of the lipopolysaccharides (LPS) from Actinobacillus pleuropneumoniae serotypes 1, 2, 5a and 5b were elucidated. The LPS's were subjected to a variety of degradative procedures. The structures of the purified products were established by monosaccharide and methylation analyses, NMR spectroscopy and mass spectrometry. The following structures for the core oligosaccharides were determined on the basis of the combined data from these experiments. For serotype 1: R is (1S)-GalaNAc-(1-->4,6)-alpha-Gal II-(1-->3)-beta-Gal I-(1-->, and R' is H For serotype 2: R is beta-Glc III-(1-->, and R' is d-alpha-d-Hep V-(1--> For serotypes 5a and 5b: R is H and R' is d-alpha-d-Hep V-(1--> All oligosaccharides elaborated a conserved inner core structure, as illustrated. All sugars were in the pyranose ring form apart from the open-chain N-acetylgalactosamine, the identification of which in the serotype 1 LPS was of interest
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberMICHAEL2004
NPARC number9372496
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Record identifier9ba77fbd-f9b0-43fb-a433-e2bb5f80f577
Record created2009-07-10
Record modified2016-05-09
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