Functional cooperation among human IgG-specific murine monoclonal antibodies for the detection of weak blood group antibodies in routine agglutination tests

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DOIResolve DOI: http://doi.org/10.1111/j.1423-0410.1993.tb02526.x
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TypeArticle
Journal titleVox Sanguinis :
ISSN00429007
Volume64
Issue2
Pages99105; # of pages: 7
SubjectAgglutination Tests; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Binding, Competitive; Blood Group Antigens; Blood Grouping and Crossmatching; Diagnostic Tests, Routine; Epitopes; Female; Humans; Immunoglobulin G; Immunoglobulin Isotypes; Isoantibodies; Mice; Mice, Inbred BALB C; Species Specificity
AbstractSeven monoclonal antibodies (MAbs) selected from a large panel of human IgG-specific murine MAbs were characterized serologically and studied for their ability to cooperate in routine antihuman globulin agglutination tests. In binding inhibition experiments, three of these MAbs were shown to bind simultaneously to immobilized human IgG molecules. Cooperation among these MAbs increased significantly the capacity of the individual MAbs to agglutinate red cells sensitized with weak blood group antibodies. These results demonstrate the usefulness of selected MAb blending for the preparation of potent antihuman IgG reagents from murine monoclonal antibodies.
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Identifier10196559
NPARC number12328124
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Record identifier9c97d304-2f29-44bc-98a2-a0c9638b2063
Record created2009-09-10
Record modified2016-05-09
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