The structure of the Escherichia coli O148 lipopolysaccharide core region and its linkage to the O-specific polysaccahride.

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DOIResolve DOI: http://doi.org/10.1016/j.carres.2010.10.012
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TypeArticle
Journal titleCarbohydrate Research
Volume346
Pages150152; # of pages: 3
SubjectEscherichia coli O148; LPS; O-Specific polysaccharide; Core; Structure
AbstractRecently it was demonstrated that Shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its O-specific polysaccharide (O-SP) from Escherichia coli O148. The O-SPs of these bacteria differ only by a galactose residue in the repeat unit of S. dysenteriae type 1 in place of a glucose residue in E. coli O148. Herein, we analyzed the core structure and its linkage to the O-SP in E. coli O148 LPS. Both were found to be identical to those of S. dysenteriae type 1 structures, further supporting the relatedness of these two bacteria. The following structure of the core with one repeat unit of the O-SP has been assigned (all have D-configuration except L-Rha):
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LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biological Sciences
Peer reviewedYes
NPARC number17652993
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Record identifier9d72ca6b-14ac-4060-831d-d1422a7a9137
Record created2011-04-01
Record modified2016-05-09
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