Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation

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DOIResolve DOI: http://doi.org/10.1074/jbc.M412653200
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TypeArticle
Journal titleJournal of Biological Chemistry
Volume280
Issue21
Pages2083320841; # of pages: 9
SubjectS100A4 protein; annexin II; angiogenesis
AbstractMany advanced tumors overexpress and secrete the S100A4 protein that is known to promote angiogenesis and metastasis development. The mechanisms of this effect and the endothelial receptor for S100A4 are both still unknown. Here we report that extracellular S100A4 interacts with annexin II, an endothelial plasminogen co-receptor. Co-localization and direct binding of S100A4 and annexin II were demonstrated, and the binding site was identified in the N-terminal region of annexin II. S100A4 alone or in a complex with annexin II accelerated tissue plasminogen activator-mediated plasminogen activation in solution and on the endothelial cell surface through interaction of the S100A4 C-terminal lysines with the lysine-binding domains of plasminogen. A synthetic peptide corresponding to the N terminus of annexin II prevented S100A4-induced plasmin formation in the endothelial cell culture. Local plasmin formation induced by circulating S100A4 could contribute to tumor-induced angiogenesis and metastasis formation that makes this protein an attractive target for new anti-cancer and anti-angiogenic therapies.
Publication date
AffiliationNational Research Council Canada; NRC Institute for Biological Sciences; NRC Biotechnology Research Institute
Peer reviewedNo
NRC number47470
SEMOV2005A
NPARC number3539808
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Record identifier9e99937e-bfbf-4f7d-b628-18f115174b30
Record created2009-03-01
Record modified2016-05-09
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