NaDyF4 nanoparticles as T2 contrast agents for ultrahigh field magnetic resonance imaging

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DOIResolve DOI: http://doi.org/10.1021/jz201664h
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TypeArticle
Journal titleThe Journal of Physical Chemistry Letters
ISSN1948-7185
Volume3
Issue4
Pages524529
AbstractA major limitation of the commonly used clinical MRI contrast agents (CAs) suitable at lower magnetic field strengths (<3.0 T) is their inefficiency at higher fields (>7 T), where next-generation MRI scanners are going. We present dysprosium nanoparticles (β-NaDyF4 NPs) as T2 CAs suitable at ultrahigh fields (9.4 T). These NPs effectively enhance T2 contrast at 9.4 T, which is 10-fold higher than the clinically used T2 CA (Resovist). Evaluation of the relaxivities at 3 and 9.4 T show that the T2 contrast enhances with an increase in NP size and field strength. Specifically, the transverse relaxivity (r2) values at 9.4 T were 64 times higher per NP (20.3 nm) and 6 times higher per Dy3+ ion compared to that at 3 T, which is attributed to the Curie spin relaxation mechanism. These results and confirming phantom MR images demonstrate their effectiveness as T2 CAs in ultrahigh field MRIs.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number21268894
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Record identifiera08cbca3-f8a0-4521-a3ff-7971d8034220
Record created2013-11-22
Record modified2017-03-23
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