Flow of blood-saline mixtures studied by time-domain optical coherence tomography

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DOIResolve DOI: http://doi.org/10.1117/12.808041
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Proceedings titleProceedings of SPIE
ConferenceOptical Diagnostics and Sensing IX, 26 January 2009, San Jose, CA, USA
Pages718607-1718607-10; # of pages: 10
Subjecttime-domain optical coherence tomography; blood; light propagation; attenuation; multiple scattering of light; blood cells; blood-saline flow
AbstractIn-vitro analysis of flowing blood-saline mixtures is performed by time-domain optical coherence tomography imaging. The mixtures contain blood in concentrations ranging from 100% to 20%. For each image, a corresponding compounded profile is obtained by adding one thousand adjacent A-scans. The compounded profiles are used for characterizing the optical coherence tomography signal as it propagates within the studied blood–saline mixtures. The results obtained point toward the possibility of acquiring intra-vascular images of arterial tissue that is located behind slabs of flowing blood-saline. A threshold in the propagation distance beyond which the recorded signal becomes dominated by its multiple scattered components is established along the compounded profiles. The threshold location, at a depth of ~0.6 mm, is independent of blood concentration. Further investigation of the compounded profiles reveals that the region extending to a maximum depth of about 200 μm from the point where the probing beam enters blood-saline mixtures could reveal information about the flow regime. This opens the possibility of another application for time-domain optical coherence tomography in intravascular imaging: assessing the flow regime, i.e. laminar or turbulent.
Publication date
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number19703847
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Record identifiera163c8ac-764d-4cb3-8b99-be717b020868
Record created2012-03-28
Record modified2016-05-09
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