New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity

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DOIResolve DOI: http://doi.org/10.1021/np0100385
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume64
Issue9
Pages11271132; # of pages: 6
AbstractThe MeOH extract of Nam ginseng (roots and rhizomes of Dracaena angustifolia) afforded nine new compounds, including three spirostanol sapogenins, named namogenins A−C (1−3), four spirostanol saponins, named namonins A−D (4−7), a furostanol saponin, named namonin E (8), and a pregnan glycoside, named namonin F (9), along with another eight known steroidal saponins (10−17). Their structures were determined on the basis of spectral analyses and chemical methods. All compounds were tested for their antiproliferative activity against murine colon 26-L5 carcinoma, human HT-1080 fibrosarcoma, and B-16 BL6 melanoma cells. Compounds 4, 5, and 10 showed potent antiproliferative activity against HT-1080 fibrosarcoma cells, having IC50 values of 0.2, 0.3, and 0.6 μM, respectively, comparable to that of doxorubicin.
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LanguageEnglish
Peer reviewedYes
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NPARC number21274806
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Record identifiera23880c2-8184-4645-a8e2-0367505bfdeb
Record created2015-04-13
Record modified2016-05-09
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