Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease

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DOIResolve DOI: http://doi.org/10.1007/s12264-011-1015-7
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TypeArticle
Journal titleNeuroscience Bulletin
Volume27
Issue4
Pages221232; # of pages: 12
Subjectmouse model; Alzheimer’s disease; β-amyloid peptides; secretase activities; DNA oxidative damage; behavioral test
AbstractThe double transgenic mouse model (APPswe/PS1dE9) of Alzheimer’s disease (AD) has been widely used in experimental studies. β-Amyloid (Aβ) peptide is excessively produced in AD mouse brain, which affects synaptic function and the development of central nervous system. However, little has been reported on characterization of this model. The present study aimed to characterize this mouse AD model and its wild-type counterparts by biochemical and functional approaches.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number19105358
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Record identifiera2c7e2c9-ccaf-425b-a489-a738da32d07a
Record created2011-12-20
Record modified2016-05-09
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