Bright-field TEM imaging of single molecules : dream or near future?

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DOIResolve DOI: http://doi.org/10.1016/j.ultramic.2006.05.001
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TypeArticle
Journal titleUltramicroscopy
Volume107
Issue1
Pages4049; # of pages: 10
Subjectbright-field TEM; field-emission source; high-resolution TEM; low-dose imaging; radiation damage; single molecule imaging; spherical aberration
AbstractWe examine the suitability of spherical aberration (CS)-corrected (CS) and uncorrected (UC) transmission electron microscopes (TEM) for conventional bright-field imaging of radiation-sensitive materials. We have chosen an individual molecule suspended in vacuum as a hypothetical example of a well-defined radiation-sensitive sample. We find that for this particular sample, CS instruments provide about 30% improvement over an UC instrument in terms of signal/noise ratio per unit electron dose at 300?kV. The lowest imaging doses can be achieved in CS instruments equipped with high-brightness electron source operated at low incident electron energies. Our calculations suggest that it may be possible to image individual, iodine- or bromine-substituted organic molecules in bright-field mode, at doses lower than the accepted values for radiation damage of aromatic molecules.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; National Institute for Nanotechnology
Peer reviewedYes
NPARC number12328075
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Record identifiera327edcc-68fd-465b-8fee-cad77f726ea3
Record created2009-09-10
Record modified2016-05-09
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