High-yield synthesis of milligram amounts of isotopically enriched methylmercury (CH₃¹⁹⁸HgCl)

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DOIResolve DOI: http://doi.org/10.1002/aoc.572
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TypeArticle
Journal titleApplied Organometallic Chemistry
ISSN0268-2605
Volume18
Issue2
Pages5764; # of pages: 8
AbstractIsotopically enriched CH₃¹⁹⁸HgCl (MeHgCl) has been synthesized from commercially available elemental ¹⁹⁸Hg (96% isotopic purity). Elemental mercury is first converted to HgCl₂ and subsequently reacted with methylcobalamin to produce MeHgCl. The resulting MeHgCl is isolated from the reaction mixture by successive extractions with toluene and dried over Na₂SO₄. The product structure was verified using gas chromatography-mass spectrometry (GC-MS) and the isotopic composition was determined by GC-inductively coupled plasma MS. The yield obtained is 99%. The proposed method allows preparation of milligram quantities of MeHgCl in one step, minimizing the cost of this synthesis.
Publication date
LanguageEnglish
AffiliationNRC Institute for National Measurement Standards; National Research Council Canada
Peer reviewedYes
NRC number458
NPARC number8897681
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Record identifiera3512957-60ea-410a-9446-8419eea9de67
Record created2009-04-22
Record modified2016-05-09
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