Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells

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DOIResolve DOI: http://doi.org/10.1039/c1cc13808a
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TypeArticle
Journal titleChemical Communications
ISSN1359-7345
Volume47
Issue36
Pages1004010042; # of pages: 3
Subjectalkyne; azide; cyclic nitrone; cyclooctyne; nitrone; unclassified drug; article; cancer cell; chemical labeling; chemical reaction; chemical structure; cycloaddition; liver cell; Alkynes; Azides; Catalysis; Cell Line, Tumor; Cyclization; Humans; Kinetics; Neoplasms; Nitrogen Oxides; Receptor, Epidermal Growth Factor
AbstractStrain-promoted cycloadditions of cyclic nitrones with cyclooctynes proceed with rate constants up to 3.38 ± 0.31 M -1 s -1 in CD 3CN, or 59 times faster than the analogous reaction of azides. This highly specific modular labeling strategy can be applied for direct labeling of proteins and for live cell imaging of cancer cells. © The Royal Society of Chemistry 2011.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Steacie Institute for Molecular Sciences (SIMS-ISSM)
Peer reviewedYes
NPARC number21271593
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Record identifiera387fa27-ed1e-4f40-b37c-2c41f01a3871
Record created2014-03-24
Record modified2016-05-09
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