Chemogenomic profiling predicts antifungal synergies

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DOIResolve DOI: http://doi.org/10.1038/msb.2009.95
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TypeArticle
Journal titleMolecular Systems Biology
Volume5
Pages338-1338-13; # of pages: 13
Subjectantifungal; chemical genomics; drug profiling; synergy predictor
AbstractChemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinformatics-driven approach that efficiently predicts compound synergy for such combinatorial therapies. The approach uses chemogenomic profiles in order to identify compound profiles that have a statistically significant degree of similarity to a fluconazole profile. The compounds identified were then experimentally verified to be synergistic with fluconazole and with each other, in both Saccharomyces cerevisiae and the fungal pathogen Candida albicans. Our method is therefore capable of accurately predicting compound synergy to aid the development of combinatorial antifungal therapies.
Publication date
LanguageEnglish
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedYes
NRC number49513
NPARC number18397755
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Record identifiera46c37fc-6d2f-4310-baa3-b7863cb0ecd0
Record created2012-03-06
Record modified2016-05-09
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