Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-Metastatic murine colon 26-L5 carcinoma cell line

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DOIResolve DOI: http://doi.org/10.1016/S0968-0896(02)00138-4
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TypeArticle
ISSN0968-0896
Volume10
Issue10
Pages33513359; # of pages: 9
AbstractCaffeic acid phenethyl ester (CAPE, 2) and its twenty analogues (1, 3–21) were prepared. These esters were tested by MTT assay on growth of murine colon 26-L5 carcinoma, murine B16-BL6 malonoma, murine Lewis lung carcinoma, human HT-1080 fibrosarcoma, human lung A549 adenocarcinoma, and human cervix HeLa adenocarcinoma cell lines. It was found that CAPE analogues possessed selective antiproliferative activity toward highly liver-metastatic murine colon 26-L5 carcinoma cell line. Among them, 4-phenylbutyl caffeate (4), (Z)-8-phenyl-7-octenyl (10a) and (E)-8-phenyl-7-octenyl (10b) caffeate showed the most potent antiproliferative activity (EC50 value, 0.02 μM). In addition, CAPE (2) induced DNA fragmentation at concentrations of 1 to 10 μg/mL towards murine colon 26-L5 carcinoma cells.
LanguageEnglish
Peer reviewedNo
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NPARC number21274776
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Record identifiera4b6d416-ff38-4e78-aad5-ca1cbda261e8
Record created2015-04-08
Record modified2017-03-23
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