Antifungal Activity of Alkaloids from the Seeds of Chimonanthus praecox

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DOIResolve DOI: http://doi.org/10.1002/cbdv.200800089
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TypeArticle
Journal titleCHEMISTRY & BIODIVERSITY
Volume6
Issue6
Pages838845; # of pages: 8
Subjectactivity; Antifungal Agents; Calycanthaceae; chemistry; drug effects; Fungi; In Vitro; Indoles; isolation & purification; Microbial Sensitivity Tests; Naphthyridines; pha; pharmacology; Pyrroles; Seeds; Vitr
AbstractTwo alkaloids, d-calycanthine (1) and l-folicanthine (2), were isolated from the active MeOH extract of the seeds of Chimonanthus praecox Link. The structures of the two compounds were established by 1H- and 13C-NMR, and MS (FAB, ESI) analyses. In the in vitro tests, compounds 1 and 2 showed significant inhibitory activities against five plant pathogenic fungi Exserohilum turcicum, Bipolaris maydis, Alternaria solani, Sclerotinia sderotiorum, and Fusarium oxysportium, among which B. maydis was found to be the most susceptible to 1 with an EC50 value of 29.3 mg/ml, followed by S. sderotiorum to 2 with an EC50 value of 61.2 mg/ml. To our knowledge, this is the first report of isolation and LC/MS/MS identification as well as of antifungal properties of these alkaloids from the seeds of this plant.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedNo
NRC number50672
NPARC number12907843
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Record identifiera52dc492-804a-4627-a301-c4eaeb1cd2ea
Record created2009-11-10
Record modified2016-05-09
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