Inhibitors of nitric oxide (NO) production in murine macrophage-like J774.1 cells from Brazilian propolis

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TypeArticle
Journal titleJournal of Traditional Medicines
ISSN1340-6302
Volume20
Issue1
Pages2229; # of pages: 8
SubjectBrazilian propolis; nitric oxide (NO); coniferyl aldehyde; dimeric coniferyl acetate; labdane-type diterpene
AbstractWater and MeOH extracts of Brazilian propolis showed dose-dependent inhibition toward nitric oxide (NO) production in lipopolysacchalide (LPS)-activated murine macrophage-like J774.1 cells. From the water extract, 17 phenolic compounds were isolated and among them 15 are new for the water extract of propolis. Moreover, methyl ρ-hydroxydihydrocinnamate (9) and 1-(4-hydroxyphenyl)butane-1,3-dione (11) were isolated, for the first time, from propolis. Labdane-type diterpenes, flavonoids and some phenolic compounds possessed potent NO inhibitory activity. Coniferyl aldehyde (23) and dimeric coniferyl acetate (33) showed the strongest NO inhibition with IC_50 values of 18.0 and 27.1 μM, respectively, which were stronger than the positive control, N^G-monomethyl-L-arginine (L-NMMA ; IC_50, 44.5 μM).
Publication date
Linkhttp://ci.nii.ac.jp/naid/110001846581
LanguageEnglish
Peer reviewedYes
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This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21274440
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Record identifiera6ac182e-b051-4d7b-88e5-1a5f9e72e18e
Record created2015-03-13
Record modified2016-05-09
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